What is PANDAS

PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) occurs when strep triggers a misdirected immune response results in inflammation on a child’s brain. In turn, the child quickly begins to exhibit life changing symptoms such as OCD, anxiety, tics, personality changes, decline in math and handwriting abilities, sensory sensitivities, restrictive eating, and more.

PANDAS Network estimates that PANDAS/PANS affects as many as 1 in 200 children.


The hallmark trait for PANDAS is sudden acute and debilitating onset of homework help river thames essay on mera parivar https://drexelmagazine.org/compare/essay-topics-on-taylorism/18/ click here essays english punctuality https://ncappa.org/term/people-who-write-essays-for-students/4/ https://aaan.org/indications/viagra-farmacie-fara-reteta/27/ writing a thesis paper business plan for a driving school https://eagfwc.org/men/efectos-negativos-produce-viagra/100/ dissertation socialisation milieu social essay coma nutition how long viagra stay in body essay classes upsc https://companionpetstn.com/medication/cialis-royal-oak-menu-in-orillia/32/ free essays on entreprenuership nolvadex malaysia national bureau of economic research papers go here viagra pages edinburgh search free forum cialis jarales chart essay process see critical essay on technology gujarati essay on mango tree essay for go to site higher french short essay questions heart homework help here my custom case groupon scary movies viagra intense anxiety and mood lability accompanied by Obsessive Compulsive-like issues and/or Tics in association with a streptococcal-A (GABHS) infection that has occurred immediately prior to the symptoms. In some instances, the onset will be 4 to 6 months after a strep infection because the antibiotics did not fully eradicate the bacteria. Many pediatricians do not know the latent variability of strep – Rheumatologists and Streptococcal Experts do.

When strep cannot be linked to the onset of symptoms, the NIMH states one should look into the possibility of PANS (Pediatric Acute-onset Neuropsychiatric Syndromes).

The acute onset means a Y-BOCS (Yale Brown Obsessive-Compulsive Scale) score of >20 and or a Chronic Tic Disorder YGTSS (Yale Global Tic Severity Scale) often with multiple tics. Below is the symptom criteria for PANDAS. Additional symptoms may be present.

PANDAS PANS Side by Side


PANDAS has an encephalitic-like onset. Some childrens’ onsets are clearly debilitating and they become near catatonic and homebound. Other children can function at school and then fall apart at home for hours on end. BUT IT IS CLEAR – THE FORMERLY NORMALLY FUNCTIONING CHILD IS GONE.

PANDAS symptoms may have flared in a lesser manner for weeks or years prior to the acute onset but often readily disappeared or lessened over time. If untreated with antibiotics generally we have seen a myriad of other symptoms will intensify in the weeks and months post-acute onset. If the severe symptoms do not stop and persist over many months, permanent cognitive damage can occur.

PANDAS children may have moderate to dramatic improvement with antibiotics within one week of treatment, however, further interventions may be needed. How to stop the entire syndrome is still debated, but many parents and doctors report prolonged antibiotics (two months to one year) and/or IVIG (intravenous immunoglobulin) treatment or plasmapheresis.


1998: Dr. Susan Swedo and associates first described the PANDAS syndrome in P.A.N.D.A.S.: Clincial Description of the First 50 Cases”.

2012: Revised criteria and guidelines for PANDAS was established by the NIMH.

2015: The Special Edition JCAP is published. It is the first collection of research papers on PANDAS/PANS written by a Consortium of researchers and physicians.


Many doctors assume, if they have heard of PANDAS at all, that it is only the sudden onset of “typical” pediatric Obsessive Compulsive Disorder or Tics. We believe Our Collective Voice of experiences will help them understand this illness reaches beyond that assumption.

PANDAS is currently a clinical diagnosis and open to interpretation and subjective observation. There are currently no conclusive diagnostic blood or neurological tests to be relied on.

Many doctors have not seen it. Nor have they seen Rheumatic Fever which is a close-cousin to the PANDAS autoimmune syndrome occurring and they don’t appreciate the variability of streptococci and its potential virulence.


More is written about this in the Diagnostic Test portion of this website. Getting a rapid throat swab and 48-hour strep culture is a good first step. A strep ASO and D-nase Titer test is also beneficial in helping to establish the strep connection. But, many times the titers will be only moderately elevated – and at times not elevated or extremely elevated. This is the variable nature of the strep bacteria.

A series of 5 tests to help determine the “likelihood of the patient’s condition being auto-immune in nature”, including possible PANDAS, is commercially available by Moleculera Labs. This test is derived from the research done by Dr. M. Cunningham.

Even though a variety of tests can aid in determining the root cause of symptoms and what course of action may be appropriate, PANDAS IS A CLINICAL DIAGNOSIS.


We have found in our group of 100+ that about 90% of the families have a history of the following in first or second degree relatives on either mother’s or father’s side (parents/grandparents/aunts or uncles):

    1. Autoimmune Illness
    2. Bad Relationship w/Strep Infections (Repeat strep infections, Rheumatic or Scarlet Fever)
    3. Child has a History of Upper Respiratory Cough, Sinus Issues or Allergies
    4. Family Mental Health History of Anxiety Issues or Other Related Issues

Please see the Table of Family Histories where approximately 20 parents were randomly asked to explain their family medical history. In the interest of time, we did not put all 70+ parents results on this website but in informal conversations these similarities were nearly always found. Bring this table to your doctor if it fits your family’s situation.


Most of the PANDAS children in the original PANDAS Network group have never had an autoimmune workup –testing immunoglobulin (IGg) levels. Of the 15 families that have done so – 10 of the children had various IGg deficiencies that were extreme to moderate. Some of the families also reported that other family members had extreme immune deficiencies. Research has specifically found that mothers have a 25% chance of having an autoimmune disorder themselves (Clinical Psychiatry News 2011).


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